Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.

@article{Burrows2010PolybromoassociatedBF,
  title={Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.},
  author={Anna Elizabeth Burrows and Agata Smogorzewska and Stephen J Elledge},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 32},
  pages={
          14280-5
        }
}
A variety of tumor-suppressor mechanisms exist to promote genome integrity and organismal survival. One such mechanism is cellular senescence. In response to replicative aging, DNA damage, and oncogenic stimuli, the p53 and Rb pathways are activated to prevent the proliferation of damaged cells by inducing senescence or apoptosis. We have performed a loss-of-function genetic screen in primary human cells to identify components of the senescence machinery. Here we describe BRD7 and BAF180 as… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

The landscape of somatic copy-number alteration across human cancers

R Beroukhim
  • Nature
  • 2010
VIEW 2 EXCERPTS

Transcriptional regulation of BRD7 expression by Sp1 and c-Myc

H Liu
  • BMC Mol Biol
  • 2008
VIEW 1 EXCERPT