Polybrominated diphenyl ethers enhance the production of proinflammatory cytokines by the placenta.

@article{Peltier2012PolybrominatedDE,
  title={Polybrominated diphenyl ethers enhance the production of proinflammatory cytokines by the placenta.},
  author={Morgan R. Peltier and Natalia G Klimova and Yuko Arita and Ellen M Gurzenda and Amitasrigowri S Murthy and Kiranpreet Chawala and Veronica T Lerner and Joy Richardson and Nazeeh Hanna},
  journal={Placenta},
  year={2012},
  volume={33 9},
  pages={745-9}
}
Polybrominated diphenyl ether(s) (PBDE) are ubiquitous environmental contaminants that bind and cross the placenta but their effects on pregnancy outcome are unclear. It is possible that environmental contaminants increase the risk of inflammation-mediated pregnancy complications such as preterm birth by promoting a proinflammatory environment at the maternal-fetal interface. We hypothesized that PBDE would reduce IL-10 production and enhance the production of proinflammatory cytokines… CONTINUE READING
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Effects of polybrominated diphenyl ethers on basal and TCDDinduced ethoxyresorufin activity and cytochrome P450-1A1 expression in MCF-7, HepG2, and H4IIE cells

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