Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects.

@article{Hallgren2002PolybrominatedDE,
  title={Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects.},
  author={Sara Hallgren and Per Ola Darnerud},
  journal={Toxicology},
  year={2002},
  volume={177 2-3},
  pages={
          227-43
        }
}
The effects of the polybrominated diphenyl ether (PBDE) congener 2,2'4, 4'-tetrabromodiphenylether (DE-47), and technical preparations of polychlorinated biphenyls (PCBs; Aroclor 1254) and chlorinated paraffins (CPs; Witaclor 171P) on thyroid hormone (TH) levels were examined in rats. To study possible interactive effects, also combinations of the three compounds were used. Thus, female Sprague-Dawley rats, 7 weeks old, were treated with approximately isomolar doses (ca. 30 micromol/kg bw per… CONTINUE READING

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