Polyaspartoyl.l-arginine inhibits platelet aggregation through stimulation of NO release from endothelial cells.

@article{Tang2008PolyaspartoyllarginineIP,
  title={Polyaspartoyl.l-arginine inhibits platelet aggregation through stimulation of NO release from endothelial cells.},
  author={Zhiyu Tang and Ming Zhao and Changling Li and Yinye Wang and Shiqi Peng},
  journal={European journal of pharmacology},
  year={2008},
  volume={588 1},
  pages={
          41-6
        }
}
Polyaspartoyl.l-arginine (PDR) is an inhibitor of platelet aggregation ex vivo but in vitro. This study attempts to elucidate the target cell of PDR action and its action mechanism. PDR (1.7-170 microg/ml) significantly inhibited platelet aggregation in vitro in the presence of rat aortic endothelial cells (RAEC), NO synthase inhibitor N-nitro-l-arginine methyl ester (l-NAME) inhibited this effect, but it was ineffective in the RAEC absence. Correspondingly, PDR increased NO level in the… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 23 REFERENCES

L-arginine infusion

M. Marietta, F. Facchinetti, I. Neri, F. Piccinini
  • 1997
VIEW 2 EXCERPTS