Polyamines potentiate responses of N-methyl-D-aspartate receptors expressed in xenopus oocytes.

@article{McGurk1990PolyaminesPR,
  title={Polyamines potentiate responses of N-methyl-D-aspartate receptors expressed in xenopus oocytes.},
  author={J F McGurk and Michael V. L. Bennett and R Suzanne Zukin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 24},
  pages={9971-4}
}
Glutamate, the major excitatory neurotransmitter in the central nervous system, activates at least three types of channel-forming receptors defined by the selective agonists N-methyl-D-aspartate (NMDA), kainate, and quisqualate [or more selectively by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)]. Activation of the NMDA receptor requires glycine as well as NMDA or glutamate. Recent studies have provided evidence that certain polyamines potentiate the binding by NMDA receptors… CONTINUE READING

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