Polyamines modulate transcription but not posttranscription of c-myc and c-jun in IEC-6 cells.

@article{Patel1997PolyaminesMT,
  title={Polyamines modulate transcription but not posttranscription of c-myc and c-jun in IEC-6 cells.},
  author={Anami R Patel and J. Y. Wang},
  journal={The American journal of physiology},
  year={1997},
  volume={273 3 Pt 1},
  pages={C1020-9}
}
The goal of the current study was to examine whether polyamines are involved in the regulation of transcription and posttranscription of the protooncogenes c-myc and c-jun in intestinal epithelial cells. Studies were conducted in the IEC-6 cell line derived from rat small intestinal crypt cells. Administration of alpha-difluoromethylornithine (DFMO), a specific inhibitor of polyamine synthesis, for 4 or 6 days not only almost completely depleted total (whole) cellular and nuclear polyamines but… CONTINUE READING

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