Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response.

@article{Iwashita2011PolyaminesMG,
  title={Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response.},
  author={Yuji Iwashita and Toshio Sakiyama and Mark W Musch and Mark J. Ropeleski and Hirohito Tsubouchi and Eugene B Chang},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2011},
  volume={301 1},
  pages={
          G181-7
        }
}
  • Yuji Iwashita, Toshio Sakiyama, +3 authors Eugene B Chang
  • Published 2011
  • Biology, Chemistry, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • Heat shock proteins (Hsps) are highly conserved proteins that play a role in cytoprotection and maintaining intestinal homeostasis. Glutamine is essential for the optimal induction of intestinal epithelial Hsp expression, but its mechanisms of action are incompletely understood. Glutamine is a substrate for polyamine synthesis and stimulates the activity of ornithine decarboxylase (ODC), a key enzyme for polyamine synthesis, in intestinal epithelial cells. Thus we investigated whether… CONTINUE READING

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    Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.

    • Yunwei Wang, Fanfei Lin, +5 authors Eugene B Chang
    • Biology, Medicine
    • American journal of physiology. Gastrointestinal and liver physiology
    • 2018
    VIEW 1 EXCERPT
    CITES BACKGROUND

    Glutamine Randomized Studies in Early Life: The Unsolved Riddle of Experimental and Clinical Studies

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