Polyamines inhibit nitric oxide synthase in rat cerebellum.

  title={Polyamines inhibit nitric oxide synthase in rat cerebellum.},
  author={J R Hu and M I Mahmoud and Esam E. El-Fakahany},
  journal={Neuroscience letters},
  volume={175 1-2},
The polyamines spermine, spermidine and putrescine share some basic structural features with L-arginine, the substrate of nitric oxide (NO) synthase. The effects of the polyamines on neuronal NO synthase activity were studied in cytosolic preparations of rat cerebellum and cultured cerebellar granule neurons. Spermine, spermidine and putrescine all inhibited the conversion of [3H]L-arginine to [3H]L-citrulline by NO synthase, with the following rank order of potency: spermine > spermidine… CONTINUE READING