Polyamines increase in sympathetic neurons and non-neuronal cells after axotomy and enhance neurite outgrowth in nerve growth factor-primed PC12 cells.

@article{Schreiber2004PolyaminesII,
  title={Polyamines increase in sympathetic neurons and non-neuronal cells after axotomy and enhance neurite outgrowth in nerve growth factor-primed PC12 cells.},
  author={Rebecca C Schreiber and Kristen L Boeshore and Gregor Laube and R{\"u}diger W Veh and Richard E Zigmond},
  journal={Neuroscience},
  year={2004},
  volume={128 4},
  pages={741-9}
}
Following axonal damage, sympathetic neurons are capable of regenerating and reinnervating their target tissues. Some years ago exogenous administration of polyamines was shown to enhance this regeneration. Recently, it was found that axonal injury leads to a dramatic up-regulation of the expression of arginase I in sympathetic neurons. This enzyme catalyzes the conversion of arginine to ornithine, which can subsequently be converted to the diamine putrescine and, ultimately, to the polyamines… CONTINUE READING
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