Polyamines can increase resistance of Neisseria gonorrhoeae to mediators of the innate human host defense.

@article{Goytia2010PolyaminesCI,
  title={Polyamines can increase resistance of Neisseria gonorrhoeae to mediators of the innate human host defense.},
  author={Maira M Goytia and William M. Shafer},
  journal={Infection and immunity},
  year={2010},
  volume={78 7},
  pages={3187-95}
}
Polyamines are biogenic polycationic molecules involved in key cellular functions. Extracellular polyamines found in bodily fluids or laboratory media can be imported by bacteria or bind to negatively charged bacterial surface structures, where they can impair binding of antimicrobials. We hypothesized that the presence of polyamines in fluids that bathe urogenital mucosal surfaces could alter the susceptibility of the sexually transmitted strict human pathogen Neisseria gonorrhoeae to… CONTINUE READING
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