Polyamines as cancer markers: applicable separation methods.

  title={Polyamines as cancer markers: applicable separation methods.},
  author={Mohammad Yar Khuhawar and G A Qureshi},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  volume={764 1-2},
Spermine, spermidine, putrescine and cadaverine are aliphatic amines widely spread in the human body. Their concentrations together with their acetyl conjugates increase significantly in the biological fluids and the affected tissues of cancer patients. Their concentrations decrease with the improvement in the patient's condition on multiple therapy. Various chromatographic techniques are frequently used in monitoring concentrations of di- and polyamines in cancer. Among these techniques, thin… CONTINUE READING


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