Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-alpha in IEC-6 cells.

@article{Bhattacharya2003PolyaminesAR,
  title={Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-alpha in IEC-6 cells.},
  author={Sujoy Bhattacharya and Ramesh Ray and Mary Jane Viar and Leonard R. Johnson},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2003},
  volume={285 5},
  pages={G980-91}
}
Intracellular polyamine homeostasis is important for the regulation of cell proliferation and apoptosis and is necessary for the balanced growth of cells and tissues. Polyamines have been shown to play a role in the regulation of apoptosis in many cell types, including IEC-6 cells, but the mechanism is not clear. In this study, we analyzed the mechanism by which polyamines regulate the process of apoptosis in response to tumor necrosis factor-alpha (TNF-alpha). TNF-alpha or cycloheximide (CHX… CONTINUE READING
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