Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells.

@article{Paz2014PolyaminesAO,
  title={Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells.},
  author={E Antonio Paz and Bonnie Lafleur and Eugene W. Gerner},
  journal={Molecular carcinogenesis},
  year={2014},
  volume={53 Suppl 1},
  pages={E96-106}
}
Polyamine metabolism is a highly coordinated process that is essential for normal development and neoplastic growth in mammals. Although polyamine metabolism is a validated pathway for prevention of carcinogenesis, the mechanisms by which polyamines elicit their tumorigenic effects are poorly understood. In this study, we investigated the role of polyamine metabolism in colon cancer by screening a non-coding RNA (ncRNA) platform to identify polyamine responsive signaling nodes. We report that… CONTINUE READING
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