Polyamines are necessary for the survival of human small-cell lung carcinoma in culture.

@article{Luk1981PolyaminesAN,
  title={Polyamines are necessary for the survival of human small-cell lung carcinoma in culture.},
  author={Gordon D. Luk and Gregory Goodwin and Laurence J. Marton and Stephen B. Baylin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 4},
  pages={2355-8}
}
Many human small-cell lung carcinoma culture lines grow as multicellular aggregate spheroids, for which high L-dopa decarboxylase activity is a marker. During the initial cell aggregation and the exponential growth phase, there is a marked increase in ornithine decarboxylase activity and an accumulation of polyamines. alpha-Difluoromethylornithine, a specific enzyme-activated, irreversible ornithine decarboxylase inhibitor, blocks the increase in ornithine decarboxylase activity and in… CONTINUE READING

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