Polyamines and Gut Mucosal Homeostasis.

  title={Polyamines and Gut Mucosal Homeostasis.},
  author={J. Michael Timmons and Elizabeth T. Chang and Jian-ying Wang and Jaladanki N. Rao},
  journal={Journal of gastrointestinal & digestive system},
  volume={2 Suppl 7}
The epithelium of gastrointestinal (GI) mucosa has the most rapid turnover rate of any tissue in the body and its integrity is preserved through the dynamic balance between cell migration, proliferation, growth arrest and apoptosis. To maintain tissue homeostasis of the GI mucosa, the rates of epithelial cell division and apoptosis must be highly regulated by various extracellular and intracellular factors including cellular polyamines. Natural polyamines spermidine, spermine and their… CONTINUE READING

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