Polyamine synthesis inhibition induces S phase cell cycle arrest in vascular smooth muscle cells

@article{Odenlund2008PolyamineSI,
  title={Polyamine synthesis inhibition induces S phase cell cycle arrest in vascular smooth muscle cells},
  author={Malin Odenlund and Bo I. Holmqvist and Bo Baldetorp and Per Hellstrand and Bengt-Olof Nilsson},
  journal={Amino Acids},
  year={2008},
  volume={36},
  pages={273-282}
}
Polyamines are important for cell growth and proliferation and they are formed from arginine and ornithine via arginase and ornithine decarboxylase (ODC). Arginine may alternatively be metabolised to NO via NO synthase. Here we study if vascular smooth muscle cell proliferation can be reversed by polyamine synthesis inhibitors and investigate their mechanism of action. Cell proliferation was assessed in cultured vascular smooth muscle A7r5 cells and in endothelium-denuded rat arterial rings by… CONTINUE READING

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