Polyamine regulation of N-methyl-D-aspartate receptor channels.

  title={Polyamine regulation of N-methyl-D-aspartate receptor channels.},
  author={Don Rock and Robert L Macdonald},
  journal={Annual review of pharmacology and toxicology},
Endogenous polyamines such as spermine and spermidine have multiple effects in the central nervous system and have been suggested to be neurotransmitters or neuromodulators. One effect of the polyamines is to regulate the activity of the N-methyl-D-aspartate receptor (NMDAR) channel subtype of glutamate receptor channels. The effects of polyamines on NMDAR currents are complex, suggesting the presence of one or more polyamine-binding sites on the receptor channel. Electrophysiological studies… CONTINUE READING