Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth.

@article{Rajeeve2013PolyaminePI,
  title={Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth.},
  author={Vinothini Rajeeve and Wayne P. Pearce and Marta Cascante and Bart Vanhaesebroeck and Pedro Rodriguez Cutillas},
  journal={The Biochemical journal},
  year={2013},
  volume={450 3},
  pages={
          619-28
        }
}
PI3K (phosphoinositide 3-kinase) signalling pathways regulate a large array of cell biological functions in normal and cancer cells. In the present study we investigated the involvement of PI3K in modulating small molecule metabolism. A LC (liquid chromatography)-MS screen in colorectal cancer cell lines isogenic for oncogenic PIK3CA mutations revealed an association between PI3K activation and the levels of polyamine pathway metabolites, including 5-methylthioadenosine, putrescine and… 
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