Polyamine metabolism as chemotherapeutic target in protozoan parasites.

  title={Polyamine metabolism as chemotherapeutic target in protozoan parasites.},
  author={Cyrus J. Bacchi and Nigel Yarlett},
  journal={Mini reviews in medicinal chemistry},
  volume={2 6},
Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic… CONTINUE READING

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A Guide to the Polyamines

S. S. Cohen
FEBS Lett., • 1998
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