Polyamine metabolism: a potential therapeutic target in trypanosomes.

  title={Polyamine metabolism: a potential therapeutic target in trypanosomes.},
  author={Cyrus J. Bacchi and Henry C. Nathan and Seymour H. Hutner and Peter P. McCann and Albert Sjoerdsma},
  volume={210 4467},
alpha-Difluoromethylornithine (RMI 71,782), a specific irreversible inhibitor of the first step in polyamine biosynthesis, that is, the formation of putrescine from ornithine by ornithine decarboxylase, cures mice infected with a virulent, rodent-passaged strain of Trypanosoma brucei brucei. This parasite is closely related to the trypanosomes that cause human sleeping sickness. The drug, which is remarkably nontoxic, was effective when administered in drinking water or by intubation. The… CONTINUE READING


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