Polyamine-mediated heart hypertrophy induced by clenbuterol in the mouse.

  title={Polyamine-mediated heart hypertrophy induced by clenbuterol in the mouse.},
  author={Juan C Cubr{\'i}a and Rosa Mar{\'i}a Reguera and Rafael Bala{\~n}a-Fouce and Carlos Ordonez and David Ord{\'o}{\~n}ez},
  journal={The Journal of pharmacy and pharmacology},
  volume={50 1},
The use of beta-agonists as growth-promoting agents in cattle could lead to toxic side-effects in man. One such effect is the accumulation of polyamines which seem to be implicated in muscle and heart hypertrophy. We have studied the induction of cardiac hypertrophy after treatment with clenbuterol and the role of polyamines in this effect. Treatment of mice with repeated doses of clenbuterol, a specific beta-adrenergic agonist, resulted in a marked increase in heart muscle weight whereas total… CONTINUE READING


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