Polyamine-mediated control of mammalian S-adenosyl-L-methionine decarboxylase expression: effects on the content and translational efficiency of the mRNA.

@article{Persson1989PolyaminemediatedCO,
  title={Polyamine-mediated control of mammalian S-adenosyl-L-methionine decarboxylase expression: effects on the content and translational efficiency of the mRNA.},
  author={Lo Persson and L Stjernborg and Ingvar Holm and Olle Heby},
  journal={Biochemical and biophysical research communications},
  year={1989},
  volume={160 3},
  pages={
          1196-202
        }
}
  • Lo Persson, L Stjernborg, +1 author Olle Heby
  • Published in
    Biochemical and biophysical…
    1989
  • Biology, Medicine
  • The expression of mammalian AdoMet decarboxylase, a key enzyme in polyamine synthesis, was shown to be regulated by polyamines at two different levels. Polyamine depletion of Ehrlich ascites tumor cells induced a marked compensatory increase in the synthesis of the enzyme, as measured by 35S-methionine pulse-labeling and immuno-precipitation. This increase in synthesis rate was counteracted by provision of spermidine, which reduced the synthesis of AdoMet decarboxylase to an undetectable level… CONTINUE READING

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