Polyamine-mediated apoptosis of alveolar macrophages during Pneumocystis pneumonia.

@article{Lasbury2007PolyaminemediatedAO,
  title={Polyamine-mediated apoptosis of alveolar macrophages during Pneumocystis pneumonia.},
  author={Mark E. Lasbury and Salim Merali and Pamela J. Durant and Dennis Tschang and Chad A Ray and Chao-Hung Lee},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 15},
  pages={
          11009-20
        }
}
The number of alveolar macrophages is decreased during Pneumocystis pneumonia (Pcp), partly because of activation of apoptosis in these cells. This apoptosis occurs in both rat and mouse models of Pcp. Bronchoalveolar lavage (BAL) fluids from Pneumocystis-infected animals were found to contain high levels of polyamines, including spermidine, N1-acetylspermine, and N1-acetylspermidine. These BAL fluids and exogenous polyamines were able to induce apoptosis in alveolar macrophages. Apoptosis of… CONTINUE READING
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