Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cells.

@article{Zou2005PolyamineDI,
  title={Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cells.},
  author={Tongtong Zou and Jaladanki N. Rao and Lan Liu and Bernard S. Marasa and Kaspar M. Keledjian and Ai-Hong Zhang and Lan Xiao and Barbara Bass and Jian-ying Wang},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={289 3},
  pages={C686-96}
}
Our previous studies have shown that polyamines are required for normal intestinal mucosal growth and that decreased levels of polyamines inhibit intestinal epithelial cell (IEC) proliferation by stabilizing p53 and other growth-inhibiting proteins. Nucleophosmin (NPM) is a multifunctional protein that recently has been shown to regulate p53 activity. In the present study, we sought to determine whether polyamine depletion increases NPM modulating the stability and transcriptional activity of… CONTINUE READING

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