Polyamine-dependent expression of the matrix metalloproteinase matrilysin in a human colon cancer-derived cell line.

@article{Wallon1994PolyaminedependentEO,
  title={Polyamine-dependent expression of the matrix metalloproteinase matrilysin in a human colon cancer-derived cell line.},
  author={U. Margaretha Wallon and L R Shassetz and Anne E Cress and George T. Bowden and Eugene W. Gerner},
  journal={Molecular carcinogenesis},
  year={1994},
  volume={11 3},
  pages={
          138-44
        }
}
Matrilysin, which is a member of the matrix metalloproteinase family and is implicated in colon cancer invasion, is expressed in human colon adenocarcinoma-derived SW1116 cells. We investigated the effect of alpha-difluoromethylornithine (DFMO) on matrilysin expression in this cell line because others have shown that DFMO can inhibit invasion and carcinogenesis in epithelial tissues, including the colon, in experimental models. DFMO reduced extracellular levels of matrilysin protein after 4 d… CONTINUE READING

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