Polyamine deficient diet to relieve pain hypersensitivity

@article{Rivat2008PolyamineDD,
  title={Polyamine deficient diet to relieve pain hypersensitivity},
  author={Cyril Rivat and Philippe G Richebe and Emilie Laboureyras and Jean Paul Laulin and Guy Simonnet},
  journal={PAIN®},
  year={2008},
  volume={137},
  pages={125-137}
}
There is a compelling body of evidence that N-methyl-d-aspartate receptors (NMDA-R) play a critical role in the development and maintenance of pain hypersensitivity. However, long-term treatments with NMDA-R antagonists are limited by unacceptable side effects. Since polyamines modulate the functioning of NMDA-R and mainly originate from normal dietary intake and bacterial metabolism in the gut, we developed a nutritional therapy based on dietary polyamine deficiency. Here, we reported that a… CONTINUE READING
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