Polyamine deficiency alters EGF receptor distribution and signaling effectiveness in IEC-6 cells.

@article{McCormack1998PolyamineDA,
  title={Polyamine deficiency alters EGF receptor distribution and signaling effectiveness in IEC-6 cells.},
  author={S A McCormack and Patrick M Blanner and B J Zimmerman and R Ray and Helen Poppleton and T B Patel and Leonard R. Johnson},
  journal={The American journal of physiology},
  year={1998},
  volume={274 1 Pt 1},
  pages={C192-205}
}
Cell growth and migration are essential processes for the differentiation, maintenance, and repair of the intestinal epithelium. Epidermal growth factor (EGF) is an important factor in the reorganization of the cytoskeleton required for both processes. Because we had previously found significant changes in the cytoskeleton during polyamine deficiency, it was of interest to know whether those changes could prevent EGF from stimulating growth and migration. Polyamine biosynthesis in IEC-6 cells… CONTINUE READING