Polyamine Synthesis from Proline in the Developing Porcine Placenta1

@inproceedings{Wu2005PolyamineSF,
  title={Polyamine Synthesis from Proline in the Developing Porcine Placenta1},
  author={Guoyao Wu and Fuller W. Bazer and Jianbo Hu and Greg A Johnson and Thomas E. Spencer},
  booktitle={Biology of reproduction},
  year={2005}
}
Abstract Polyamines (putrescine, spermidine, and spermine) are essential for placental growth and angiogenesis. However, little is known about polyamine synthesis in the porcine placenta during conceptus development. The present study was conducted to test the hypothesis that arginine and proline are the major sources of ornithine for placental polyamine production in pigs. Placentae, amniotic fluid, and allantoic fluid were obtained from gilts on Days 20, 30, 35, 40, 45, 50, 60, 90, and 110 of… Expand
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Arginine, Agmatine, and Polyamines: Key Regulators of Conceptus Development in Mammals.
TLDR
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TLDR
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TLDR
Dietary supplementation with Pro improved fetal pig growth and intestinal epithelial cell proliferation via enhancing polyamine synthesis through enhancing polyamines synthesis in vivo and in vitro. Expand
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Evaluated developmental changes of polyamine concentrations in IUGR and normal porcine fetuses as well as autophagic marker levels in the fetal intestinal mucosa support the notion that enhanced autophagy may be an important survival mechanism in IugR fetuses. Expand
Transcriptomic analysis of polyamine-related genes and polyamine levels in placenta, yolk sac and fetus during the second half of mouse pregnancy.
TLDR
The results suggest that the elevated polyamine biosynthetic activity of mouse placenta is required to satisfy the high demand of polyamines required by the growing fetus, during the later period of pregnancy. Expand
Putrescine Stimulates the mTOR Signaling Pathway and Protein Synthesis in Porcine Trophectoderm Cells1
TLDR
Results indicate that putrescine promotes cell proliferation and protein synthesis in a dose- and time-dependent manner, which was inhibited by difluoro-methylornithine (an inhibitor of ornithine decarboxylase), and reveals a novel and important role for putresCine in regulating the mTOR signaling pathway in porcine placental cells. Expand
Running title: Polyamines and mTOR signaling
TLDR
Findings reveal a novel and important role for putrescine in placental growth retardation and promotes cell proliferation and protein synthesis in a dose- and time-dependent manner, which was inhibited by difluoro-methylornithine. Expand
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