Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

@article{Shadrack2018PolyamidoamineDF,
  title={Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies},
  author={D. M. Shadrack and H. Swai and Joan J E Munissi and E. Mubofu and Stephen S Nyandoro},
  journal={Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry},
  year={2018},
  volume={23}
}
  • D. M. Shadrack, H. Swai, +2 authors Stephen S Nyandoro
  • Published 2018
  • Chemistry, Medicine
  • Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
    • Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties. Experimental and computational studies have reported on the therapeutic potential of polyamidoamine (PAMAM) dendrimers as solubility enhancers in pre-clinical and clinical settings. Besides formulation strategies, factors such as pH, PAMAM dendrimer generation, PAMAM dendrimer concentration, nature of the PAMAM core, special ligand and… CONTINUE READING
    View PDF
    15 Citations
    Background Citations
    3
    15 Citations
    Citation Type

    Citation Type

    Applications and Limitations of Dendrimers in Biomedicine
    • 1
    • PDF
    Smart nanocarriers for cancer treatment: Clinical impact and safety
    • 1
    PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review
    • 2
    • PDF
    The Effect of Absorption-Enhancement and the Mechanism of the PAMAM Dendrimer on Poorly Absorbable Drugs
    • 2
    • PDF
    Complexation of methotrexate via ligand diffusion molecular dynamic simulations under neutral, basic, and acidic conditions.
    • 1
    Influence cationic and anionic PAMAM dendrimers of low generation on selected hemostatic parameters in vitro.
    • 1
    β‐Cyclodextrin PAMAM Dendrimer: How to Overcome the Tumbling Process for Getting Fully Available Host Cavities
    • 2
    • PDF
    Synthesis and Different Effects of Biotinylated PAMAM G3 Dendrimer Substituted with Nimesulide in Human Normal Fibroblasts and Squamous Carcinoma Cells
    • 4
    • PDF
    The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties
    • 5
    • PDF
    Nanotechnology Applications to Improve Solubility of Bioactive Constituents of Foods for Health-Promoting Purposes

    References

    SHOWING 1-10 OF 67 REFERENCES
    Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules
    • 53
    • PDF
    Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues
    • 268
    Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy
    • 176
    • PDF
    Prolonged drug delivery system of an antifungal drug by association with polyamidoamine dendrimers
    • J. Jose, R. Charyulu
    • Medicine, Materials Science
    • International journal of pharmaceutical investigation
    • 2016
    • 19
    Bioapplications of poly(amidoamine) (PAMAM) dendrimers in nanomedicine
    • 74
    Poly(amidoamine) Dendrimers as a Pharmaceutical Excipient. Are We There yet?
    • 19
    PAMAM dendrimers in drug delivery: loading efficacy and polymer morphology
    • 12
    Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers.
    • 142
    Solubility enhancement and targeted delivery of a potent anticancer flavonoid analogue to cancer cells using ligand decorated dendrimer nano-architectures.
    • 30
    • Highly Influential
    Dendrimer encapsulated and conjugated delivery of berberine: A novel approach mitigating toxicity and improving in vivo pharmacokinetics.
    • 35
    • Highly Influential