Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease

@article{Mandel2006PolyadenylationFC,
  title={Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease},
  author={Corey R. Mandel and Syuzo Kaneko and Hailong Zhang and Damara Gebauer and Vasupradha Vethantham and James L Manley and Liang Tong},
  journal={Nature},
  year={2006},
  volume={444},
  pages={953-956}
}
The crystal structure of CPSF-73, part of a complex involved in mRNA cleavage and polyadenylation is solved. CPSF-73 was purified and shown to endonucleolytically cleave mRNA, in a reaction mediated by two zinc ligands.AbstractMost eukaryotic messenger RNA precursors (pre-mRNAs) undergo extensive maturational processing, including cleavage and polyadenylation at the 3′-end1,2,3,4,5,6,7,8. Despite the characterization of many proteins that are required for the cleavage reaction, the identity of… CONTINUE READING

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