Polyacetylene glycoside attenuates ischemic kidney injury by co‐inhibiting inflammation, mitochondria dysfunction and lipotoxicity

  title={Polyacetylene glycoside attenuates ischemic kidney injury by co‐inhibiting inflammation, mitochondria dysfunction and lipotoxicity},
  author={Yijie Zhou and D. Du and Shuyun Liu and M. Zhao and Yujia Yuan and Lan Li and Younan Chen and Y. Lu and Jingqiu Cheng and Jingping Liu},
  journal={Life Sciences},
Aims: Ischemic acute kidney injury (AKI) is a serious clinical problem and no efficient therapeutics is available in clinic now. Natural polyacetylene glycosides (PGAs) had shown antioxidant and anti‐inflammatory properties, but their effects on kidney injury have not been evaluated. This study aimed to investigate the protective effect of PGA on ischemic kidney injury in renal tubular epithelial cells (TECs) and mice. Main methods: Hypoxic HK‐2 cells and renal ischemia/reperfusion injury (IRI… Expand
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