Polyacetylene diols with antiproliferative and driving Th1 polarization effects from the marine sponge Callyspongia sp.

@article{Umeyama2009PolyacetyleneDW,
  title={Polyacetylene diols with antiproliferative and driving Th1 polarization effects from the marine sponge Callyspongia sp.},
  author={Akemi Umeyama and Nanae Matsuoka and Rieko Mine and Akemi Nakata and Eri Arimoto and Miwa Matsui and Noboru Shoji and Shigenobu Arihara and Masao Takei and Toshihiro Hashimoto},
  journal={Journal of Natural Medicines},
  year={2009},
  volume={64},
  pages={93-97}
}
A screening of 30 crude extracts of marine sponges against human promyelocytic leukemia cells (HL-60) yielded an EtOAc extract of the sponge Callyspongia sp. (Callyspongiidae) with significant activity. Further bioassay-guided fractionation of the EtOAc extract led to the isolation of three polyacetylene metabolites: a new polyacetylene diol, callyspongidiol (1), along with two known compounds, siphonodiol (2) and 14,15-dihydrosiphonodiol (3). Their structures were determined by a combination… CONTINUE READING
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