PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta.

@article{Duluc2009PolyICPI,
  title={PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta.},
  author={Doroth{\'e}e Duluc and Fang Tan and Mari Scotet and Simon Blanchard and Isabelle Fremaux and Erwan Garo and Branka Horvat and Pierre Eid and Yves Delneste and Pascale Jeannin},
  journal={European journal of immunology},
  year={2009},
  volume={39 10},
  pages={2877-84}
}
NK lymphocytes and type I IFN (IFN-alpha/beta) are major actors of the innate anti-viral response that also influence adaptive immune responses. We evaluated type I IFN production by human NK cells in response to polyI:C, a potent type I IFN-inducing TLR3 agonist. PolyI:C plus IL-2/IL-12 induced IFN-beta (but not IFN-alpha) mRNA expression and protein production by highly pure human NK cells and by the human NK cell line NK92. Neutralizing anti-IFNAR1 or anti-IFN-beta Ab prevented the… CONTINUE READING
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