PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo.

@article{Takemura2015PolyICInducedTN,
  title={PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo.},
  author={Ryo Takemura and Hiromi Takaki and Seiji Okada and Hiroaki Shime and Takashi Akazawa and Hiroyuki Oshiumi and Misako Matsumoto and Takanori Teshima and Tsukasa Seya},
  journal={Cancer immunology research},
  year={2015},
  volume={3 8},
  pages={902-14}
}
Double-stranded RNA directly acts on fibroblast and myeloid lineages to induce necroptosis as in TNFα. Here, we investigated whether this type of cell death occurred in cancer cells in response to polyinosinic-polycytidylic acid (polyI:C) and the pan-caspase inhibitor z-Val-Ala-Asp fluromethyl ketone (zVAD). We found that the colon cancer cell line CT26 is highly susceptible to necroptosis, as revealed by staining with annexin V/propidium iodide. CT26 cells possess RNA sensors, TLR3 and MDA5… CONTINUE READING
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