Poly-ubiquitination in TNFR1-mediated necroptosis

  title={Poly-ubiquitination in TNFR1-mediated necroptosis},
  author={Yves Dondelinger and Maurice Darding and Mathieu M J Bertrand and Henning Walczak},
  booktitle={Cellular and Molecular Life Sciences},
Tumor necrosis factor (TNF) is a master pro-inflammatory cytokine, and inappropriate TNF signaling is implicated in the pathology of many inflammatory diseases. Ligation of TNF to its receptor TNFR1 induces the transient formation of a primary membrane-bound signaling complex, known as complex I, that drives expression of pro-survival genes. Defective complex I activation results in induction of cell death, in the form of apoptosis or necroptosis. This switch occurs via internalization of… CONTINUE READING