Poly specific trans-acyltransferase machinery revealed via engineered acyl-CoA synthetases.

Abstract

Polyketide synthases construct polyketides with diverse structures and biological activities via the condensation of extender units and acyl thioesters. Although a growing body of evidence suggests that polyketide synthases might be tolerant to non-natural extender units, in vitro and in vivo studies aimed at probing and utilizing polyketide synthase… (More)
DOI: 10.1021/cb3003489

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