Poly r(C) binding protein-1 is central to maintenance of cancer stem cells in prostate cancer cells.

@article{Chen2015PolyRB,
  title={Poly r(C) binding protein-1 is central to maintenance of cancer stem cells in prostate cancer cells.},
  author={Qi Chen and Zhi-kang Cai and Yan-bo Chen and Meng Gu and Da-chao Zheng and Juan Zhou and Zhong Wang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2015},
  volume={35 3},
  pages={1052-61}
}
AIMS To investigate global proteomic changes induced in CD44+CD24- stem cells isolated from the prostate cancer cell lines, LNCaP and DU145, post prolonged TGF-β treatment in order to understand underlying mechanisms that promote stemness in prostate cancer cells. METHODS CD44+CD133+α2β1Integrin+CD24- population was isolated from mock or TGF-β treated (7 days) prostate cancer cell line, LNCaP, through fluorescent activated cell sorting. Cell lysates were obtained from the ±TGF-β cell… CONTINUE READING
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