Poly lactic acid--caprolactone copolymer tube with a denatured skeletal muscle segment inside as a guide for peripheral nerve regeneration: a morphological and electrophysiological evaluation of the regenerated nerves.

@article{Mligiliche2003PolyLA,
  title={Poly lactic acid--caprolactone copolymer tube with a denatured skeletal muscle segment inside as a guide for peripheral nerve regeneration: a morphological and electrophysiological evaluation of the regenerated nerves.},
  author={Nurru Lameck Mligiliche and Yasuhiko Tabata and Masaaki Kitada and Katsuaki Endoh and Keiko Okamato and Etsuko Fujimoto and Chizuka Ide},
  journal={Anatomical science international},
  year={2003},
  volume={78 3},
  pages={156-61}
}
A biodegradable copolymer of poly L-lactic acid and epsilon-caprolactone (PLAC) was manufactured into a tube, in which a denatured skeletal muscle segment was placed longitudinally. This model tube was implanted as a guide to promote nerve regeneration across a 5 cm gap in the rabbit sciatic nerve. Five months after implantation, good nerve regeneration was found throughout the graft and in the distal host nerve. The population (29.6/16 x 10(2) microm(2)) of regenerated nerves in the graft was… CONTINUE READING

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