Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat

@inproceedings{Edwards2018PolyarginineRA,
  title={Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat},
  author={Adam B Edwards and Jane L. Cross and Ryan S. Anderton and Neville W. Knuckey and Bruno P Meloni},
  booktitle={Molecular Brain},
  year={2018}
}
We examined the neuroprotective efficacy of the poly-arginine peptide R18 and its D-enantiomer R18D in a perinatal hypoxic-ischaemic (HI) model in P7 Sprague-Dawley rats. R18 and R18D peptides were administered intraperitoneally at doses of 30, 100, 300 or 1000 nmol/kg immediately after HI (8% O2/92%N2 for 2.5 h). The previously characterised neuroprotective JNKI-1-TATD peptide at a dose of 1000 nmol/kg was used as a control. Infarct volume and behavioural outcomes were measured 48 h after HI… CONTINUE READING
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Poly - arginine R 18 and R 18 D ( D - enantiomer ) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic - ischaemic encephalopathy in the P 7 rat

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  • Molecular Brain
  • 2018