Poly-Saturated Dolichols from Filamentous Fungi Modulate Activity of Dolichol-Dependent Glycosyltransferase and Physical Properties of Membranes

@article{Gryz2019PolySaturatedDF,
  title={Poly-Saturated Dolichols from Filamentous Fungi Modulate Activity of Dolichol-Dependent Glycosyltransferase and Physical Properties of Membranes},
  author={Elżbieta Gryz and U. Perlińska-Lenart and Katarzyna Gawarecka and A. Jozwiak and Sebastian Piłsyk and A. Lipko and M. Jemioła-Rzemińska and P. Bernat and A. Muszewska and Kamil Steczkiewicz and K. Ginalski and J. Długoński and K. Strzal̵ka and E. Swiezewska and J. Kruszewska},
  journal={International Journal of Molecular Sciences},
  year={2019},
  volume={20}
}
Mono-saturated polyprenols (dolichols) have been found in almost all Eukaryotic cells, however, dolichols containing additional saturated bonds at the ω-end, have been identified in A. fumigatus and A. niger. Here we confirm using an LC-ESI-QTOF-MS analysis, that poly-saturated dolichols are abundant in other filamentous fungi, Trichoderma reesei, A. nidulans and Neurospora crassa, while the yeast Saccharomyces cerevisiae only contains the typical mono-saturated dolichols. We also show, using… Expand
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