Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery.

  title={Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery.},
  author={Sandy Budi Hartono and Wenyi Gu and Freddy Kleitz and Jian Liu and Lizhong He and Anton P. J. Middelberg and Chengzhong Yu and G Q Max Lu and Shi Zhang Qiao},
  journal={ACS nano},
  volume={6 3},
Large pore mesoporous silica nanoparticles (LP-MSNs) functionalized with poly-L-lysine (PLL) were designed as a new carrier material for gene delivery applications. The synthesized LP-MSNs are 100-200 nm in diameter and are composed of cage-like pores organized in a cubic mesostructure. The size of the cavities is about 28 nm with an entrance size of 13.4 nm. Successful grafting of PLL onto the silica surface through covalent immobilization was confirmed by X-ray photoelectron spectroscopy… CONTINUE READING
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