Poly I:C Accelerates Development of Diabetes Mellitus in Diabetes-Prone BB Rat

@article{Ewel1992PolyIA,
  title={Poly I:C Accelerates Development of Diabetes Mellitus in Diabetes-Prone BB Rat},
  author={Cynthia H Ewel and D. Sobel and B. Zeligs and J. Bellanti},
  journal={Diabetes},
  year={1992},
  volume={41},
  pages={1016 - 1021}
}
We developed a new experimental model of accelerated diabetes mellitus in the genetically susceptible diabetes-prone BB rat with the administration of the IFN-α inducer poly I:C. With this model, there was both an increased incidence and accelerated onset of insulin-dependent-diabetes in poly I:C–treated animals compared with saline-treated controls. All twelve rats administered poly I:C (5 μg/gm body weight 3 times/wk) developed diabetes by 57 days of age (100%) compared with 1 of 27 (3.7… Expand
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