Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation.

@article{Ozaki2012PolyADPRO,
  title={Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation.},
  author={Yuko Ozaki and Hirotaka Matsui and Hiroya Asou and Akiko Nagamachi and Daisuke Aki and Hiroaki Honda and Shin'ichiro Yasunaga and Yoshihiro Takihara and Tadashi Yamamoto and Shunsuke Izumi and Miho Ohsugi and Toshiya Inaba},
  journal={Molecular cell},
  year={2012},
  volume={47 5},
  pages={694-706}
}
During prometaphase, dense microtubule nucleation sites at centrosomes form robust spindles that align chromosomes promptly. Failure of centrosome maturation leaves chromosomes scattered, as seen routinely in cancer cells, including myelodysplastic syndrome (MDS). We previously reported that the Miki (LOC253012) gene is frequently deleted in MDS patients… CONTINUE READING