Poly ADP-ribose polymerase-1: Beyond transcription and towards differentiation.

@article{Jubin2017PolyAP,
  title={Poly ADP-ribose polymerase-1: Beyond transcription and towards differentiation.},
  author={Tina Jubin and Ashlesha A Kadam and Amina Rafath Gani and Mala Lange Lis Singh and Mitesh Dwivedi and Rasheedunnisa Begum},
  journal={Seminars in cell & developmental biology},
  year={2017},
  volume={63},
  pages={
          167-179
        }
}
Gene regulation mediates the processes of cellular development and differentiation leading to the origin of different cell types each having their own signature gene expression profile. However, the compact chromatin structure and the timely recruitment of molecules involved in various signaling pathways are of prime importance for temporal and spatial gene regulation that eventually contribute towards cell type and specificity. Poly (ADP-ribose) polymerase-1 (PARP-1), a 116-kDa nuclear… CONTINUE READING
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