Poly ( ADP-ribose ) Polymerase Activity Prevents Signaling Pathways for Cell Cycle Arrest following DNA Methylating Agent Exposure

@inproceedings{Horton2005PolyA,
  title={Poly ( ADP-ribose ) Polymerase Activity Prevents Signaling Pathways for Cell Cycle Arrest following DNA Methylating Agent Exposure},
  author={Julie K. Horton and Donna F. Stefanick and Jana M. Naron and Padmini Kedar and Samuel H. Wilson},
  year={2005}
}
Mouse fibroblasts, deficient in DNA polymerase ß (ß-pol), are hypersensitive to monofunctional DNA methylating agents such as methyl methanesulfonate (MMS). Both wild-type, and in particular repair deficient ßpol null cells, are highly sensitized to the cytotoxic effects of MMS by 4-amino-1,8naphthalimide (4-AN), an inhibitor of poly(ADP-ribose) polymerase (PARP) activity. Experiments with synchronized cells suggest that exposure during S-phase of the cell cycle is required for the 4-AN effect… CONTINUE READING

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