Poly (Lactide-co-Glycolide) Microspheres in Respirable Sizes Enhance an In Vitro T Cell Response to Recombinant Mycobacterium tuberculosis Antigen 85B

@article{Lu2007PolyM,
  title={Poly (Lactide-co-Glycolide) Microspheres in Respirable Sizes Enhance an In Vitro T Cell Response to Recombinant Mycobacterium tuberculosis Antigen 85B},
  author={Dongmei Lu and Lucila Garcia-Contreras and Ding Xu and Sherry L. Kurtz and Jian Liu and Miriam Braunstein and David Neil McMurray and Anthony James Hickey},
  journal={Pharmaceutical Research},
  year={2007},
  volume={24},
  pages={1834-1843}
}
To investigate the use of poly (lactide-co-glycolide) (PLGA) microparticles in respirable sizes as carriers for Antigen 85B (Ag85B), a secreted protein of Mycobacterium tuberculosis, with the ultimate goal of employing them in pulmonary delivery of tuberculosis vaccine. Recombinant Ag85B was expressed from two Escherichia coli strains and encapsulated by spray-drying in PLGA microspheres with/without adjuvants. These microspheres containing rAg85B were assessed for their ability to deliver… CONTINUE READING

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