Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential.

  title={Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential.},
  author={Wookee Min and Zhao-Qi Wang},
  journal={Frontiers in bioscience},
Poly (ADP-robose) glycohydrolase (PARG) is a catabolic enzyme that cleaves ADP-ribose polymers synthesized by members of the poly (ADP-ribose) polymerase (PARP) family of enzymes. The growing evidence supports the importance of a tight control of poly (ADP-ribose) metabolism by the two major enzymes, PARP-1 and PARG. Recent studies have advanced the understanding of PARPs' and PARG's functions in various cellular and physiological processes. In the last 10 years, homeostasis of poly (ADP… CONTINUE READING