Poly(methylidene malonate 2.1.2) nanoparticles: a biocompatible polymer that enhances peri-adventitial adenoviral gene delivery.

@article{Qiang2004PolymethylideneM2,
  title={Poly(methylidene malonate 2.1.2) nanoparticles: a biocompatible polymer that enhances peri-adventitial adenoviral gene delivery.},
  author={B. Qiang and A. Segev and I. Beliard and N. Nili and B. Strauss and M. Sefton},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2004},
  volume={98 3},
  pages={
          447-55
        }
}
  • B. Qiang, A. Segev, +3 authors M. Sefton
  • Published 2004
  • Chemistry, Medicine
  • Journal of controlled release : official journal of the Controlled Release Society
Vascular gene therapy is currently limited by low and transient levels of gene transfection. The objectives of this study were to determine whether peri-adventitial delivery of adenovirus coupled to nanoparticles could improve transfection efficiency and duration. Adenovirus was absorbed to the surface of nanoparticles that were made from poly(methylidene malonate)2.1.2 (PMM2.1.2). These complexes were found to have good adhesive properties to both cultured vascular smooth muscle cells and to… Expand
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References

SHOWING 1-10 OF 16 REFERENCES
Novel microparticulate system made of poly(methylidene malonate 2.1.2).
  • 19
Adenoviral vectors and gene transfer to the blood vessel wall.
  • T. O’Brien
  • Biology, Medicine
  • Arteriosclerosis, thrombosis, and vascular biology
  • 2000
  • 14
Photopolymerizable hydrogels for tissue engineering applications.
  • 1,265
  • PDF
Arterial Elastase Activity After Balloon Angioplasty and Effects of Elafin, an Elastase Inhibitor
  • 27
  • PDF
...
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