Poly(ethylene glycol)-induced and temperature-dependent phase separation in fluid binary phospholipid membranes.

@article{Lehtonen1995PolyethyleneGA,
  title={Poly(ethylene glycol)-induced and temperature-dependent phase separation in fluid binary phospholipid membranes.},
  author={Jukka Y. A. Lehtonen and Paavo K. J. Kinnunen},
  journal={Biophysical journal},
  year={1995},
  volume={68 2},
  pages={
          525-35
        }
}
Exclusion of the strongly hygroscopic polymer, poly(ethylene glycol) (PEG), from the surface of phosphatidylcholine liposomes results in an osmotic imbalance between the hydration layer of the liposome surface and the bulk polymer solution, thus causing a partial dehydration of the phospholipid polar headgroups. PEG (average molecular weight of 6000 and in concentrations ranging from 5 to 20%, w/w) was added to the outside of large unilamellar liposomes (LUVs). This leads to, in addition to the… Expand
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