Poly(butylcyanoacrylate) and Poly(ε-caprolactone) Nanoparticles Loaded with 5-Fluorouracil Increase the Cytotoxic Effect of the Drug in Experimental Colon Cancer

@article{Ortiz2015PolybutylcyanoacrylateAP,
  title={Poly(butylcyanoacrylate) and Poly(ε-caprolactone) Nanoparticles Loaded with 5-Fluorouracil Increase the Cytotoxic Effect of the Drug in Experimental Colon Cancer},
  author={Ra{\'u}l Ortiz and Laura Cabeza and Jos{\'e} Luis Arias and Consolaci{\'o}n Melguizo and P. J. {\'A}lvarez and Celia V{\'e}lez and Beatriz Clares and Antonia {\'A}ranega and J. C. Prados},
  journal={The AAPS Journal},
  year={2015},
  volume={17},
  pages={918-929}
}
The clinical use of 5-fluorouracil, one of the drugs of choice in colon cancer therapy, is limited by a nonuniform oral absorption, a short plasma half-life, and by the development of drug resistances by malignant cells. We hypothesized that the formulation of biodegradable nanocarriers for the efficient delivery of this antitumor drug may improve its therapeutic effect against advanced or recurrent colon cancer. Hence, we have engineered two 5-fluorouracil-loaded nanoparticulate systems based… CONTINUE READING
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